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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/25142

    標題: Cytotoxic effect of Discosoma sp., Isis hippuris and Nephthea chabrolii on human oral SCC25 cells
    作者: Chia-Hua Liang
    Tzung-Han Chou
    Chau-Chen Yang
    Wei Jing Hung
    Li-Ching Chang
    Da-Long Cheng
    Guey-Horng Wang
    貢獻者: 化粧品應用與管理系
    關鍵字: Discosoma sp.
    Isis hippuris
    Nephthea chabrolii
    Cytotoxic effect
    日期: 2010-05
    上傳時間: 2012-03-29 13:45:58 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Cytotoxic effect of Discosoma sp., Isis hippuris and Nephthea chabrolii extracts on human oral squamous cell carcinoma SCC25 cells was investigated herein. The three marine extracts reduce the cell attachment and exhibit a dose-dependent cytotoxic effect. I. hippuris extract exhibited greater activity in inhibiting cell growth than Discosoma sp. and N. chabrolii. After cells were treated with three extracts, morphological alterations of cells such as rounding and membrane blebbing, nuclear condensation and apoptotic bodies are observed. The three extracts sensitized cells in the G0/G1 and S-G2/M phases with a concomitant significantly increased sub-G1 fraction, determined by flow cytometry. This apoptosis process was accompanied by up-regulation of Fas and activation of caspase-3 expression. These results imply that the three extracts caused apoptosis of SCC25 cells.
    關聯: Journal of the Taiwan Institute of Chemical Engineers 41(3):p.333-337
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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