Cytotoxic effect of Discosoma sp., Isis hippuris and Nephthea chabrolii on human oral SCC25 cells

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Title:	Cytotoxic effect of Discosoma sp., Isis hippuris and Nephthea chabrolii on human oral SCC25 cells
Authors:	Chia-Hua Liang Tzung-Han Chou Chau-Chen Yang Wei Jing Hung Li-Ching Chang Da-Long Cheng Guey-Horng Wang
Contributors:	化粧品應用與管理系
Keywords:	Discosoma sp. Isis hippuris Nephthea chabrolii Cytotoxic effect Apoptosis
Date:	2010-05
Issue Date:	2012-03-29 13:45:58 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	Cytotoxic effect of Discosoma sp., Isis hippuris and Nephthea chabrolii extracts on human oral squamous cell carcinoma SCC25 cells was investigated herein. The three marine extracts reduce the cell attachment and exhibit a dose-dependent cytotoxic effect. I. hippuris extract exhibited greater activity in inhibiting cell growth than Discosoma sp. and N. chabrolii. After cells were treated with three extracts, morphological alterations of cells such as rounding and membrane blebbing, nuclear condensation and apoptotic bodies are observed. The three extracts sensitized cells in the G0/G1 and S-G2/M phases with a concomitant significantly increased sub-G1 fraction, determined by flow cytometry. This apoptosis process was accompanied by up-regulation of Fas and activation of caspase-3 expression. These results imply that the three extracts caused apoptosis of SCC25 cells.
Relation:	Journal of the Taiwan Institute of Chemical Engineers 41(3)：p.333-337
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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