Effects of ethanolic extract from Polygonum cuspidatum on EBV-positive tumor cells

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Title:	Effects of ethanolic extract from Polygonum cuspidatum on EBV-positive tumor cells
Authors:	Shih-Ying Chen Yi-Pin Chen Tsuey-Pin Lin
Contributors:	生活應用與保健系
Keywords:	Polygonum cuspidatum EBV
Date:	2009-05-22
Issue Date:	2011-10-28 09:54:35 (UTC+8)
Abstract:	Epstein-Barr virus (EBV)-encoded latent membrane 1(LMP1) have oncogenic properties. This study is to investigate that effect of ethanolic extract from Polygonum cuspidatum (PcE) on EBV-positive tumor cells. Immunoblot was performed for the expression of LMP1. The unclear chromatin morphology and percentage of apoptotic cells was mwasured by fluorescence DNA-binding dye and flow cytometry, respectively. The viability of B95-8 cells decreased when they treated with PcE in time and dose dependent manner. The PcE effectively inhibit the expression of EBV LMP1 at 50 ug/ml and cells display typical features of apoptosis. This study finds that PcE inhibit the expression of LMP1 and improve the apoptosis, and that may be a useful therapeutic drug to EBV-positive tumor cell.
Relation:	第35屆營養年會暨學術研討會，起迄日：2009/5/22~2009/5/23，地點：靜宜大學
Appears in Collections:	[Dept. of Life and Health Science] Proceedings

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