Emesis Induced by Cancer Chemotherapeutic Agents in the Suncus Murinus: A New Experimental Model

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 14期 (1988) > Item 310902800/24366

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標題:	Emesis Induced by Cancer Chemotherapeutic Agents in the Suncus Murinus: A New Experimental Model
作者:	Norio MATSUKI Shinya UENO Takahide KAJI Akane ISHIHARA Chao-Hsiung WANG Hiroshi SAITO
日期:	1988
上傳時間:	2011-10-06 11:21:11 (UTC+8)
摘要:	Acute emetic responses to seven cancer chemotherapeutic agents (adriamycin, bleomycin, cisplatin, cyclophosphamide, 5-fluorouracil, methotrexate, mitomycin C) were studied in the Suncus murinus. Intravenous injection of the drugs caused vomiting with various latency. Cisplatin-induced emesis was prevented by the pretreatment with metoclopramide or chlorpromazine but not with domperidone. These results indicate that the Suncus murinus is a useful animal for testing emetic activities of cancer chemotherapeutics and antiemetic activities of prophylactic drugs.
關聯:	嘉南學報 14期：p.A5-A8 轉載 The Japanese Journal of Pharmacology 48(2) : p.303-306 (1988)
显示于类别:	[嘉南學報] 14期 (1988)

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