Emesis Induced by Cancer Chemotherapeutic Agents in the Suncus Murinus: A New Experimental Model

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Title:	Emesis Induced by Cancer Chemotherapeutic Agents in the Suncus Murinus: A New Experimental Model
Authors:	Norio MATSUKI Shinya UENO Takahide KAJI Akane ISHIHARA Chao-Hsiung WANG Hiroshi SAITO
Date:	1988
Issue Date:	2011-10-06 11:21:11 (UTC+8)
Abstract:	Acute emetic responses to seven cancer chemotherapeutic agents (adriamycin, bleomycin, cisplatin, cyclophosphamide, 5-fluorouracil, methotrexate, mitomycin C) were studied in the Suncus murinus. Intravenous injection of the drugs caused vomiting with various latency. Cisplatin-induced emesis was prevented by the pretreatment with metoclopramide or chlorpromazine but not with domperidone. These results indicate that the Suncus murinus is a useful animal for testing emetic activities of cancer chemotherapeutics and antiemetic activities of prophylactic drugs.
Relation:	嘉南學報 14期：p.A5-A8 轉載 The Japanese Journal of Pharmacology 48(2) : p.303-306 (1988)
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.14 (1988)

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