Lactositol為良好之賦形劑，但多量卻會引起下痢作用，因而影響配合藥物之生體可用率，本篇論文係研究Lactositol對消化道之影響，所得結果如下:併用Lactositol時(1)對胃內容物排出速度，Lactositol濃度低時為促進其排出速度，等張濃度以上時反而排出速度受到抑制。可促進小腸的輸送能。腸管腔內水分的移動受到抑制。小腸蠕動運動亢進。 Lactositol was a proper excipient. But overdose of Lactositol would cause diarrhea, and affected the bioavailability of medications in which it contains. This thesis focused on the influence of Lactositol on alimentary tract. From our research, we got the follow-mg results:
(1) Lactositol at low concentration promoted the releasing speed of contents in the stomach, but at high concentration slowed the releasing speed of contents in the stomach.
(2) Lactositol promoted the intestinal transfer.
(3) Lactositol restrained the movement of water in intestinal lumen.
(4) Lactositol strengthened the movement of intestine.
