A Novel Metabolic Products From Thermophilic Fungus , Aspergillus terreus : Ergotetranone A-D

CNU IR > Pharmacy and Science > 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium > Item 310902800/24263

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Title:	A Novel Metabolic Products From Thermophilic Fungus , Aspergillus terreus : Ergotetranone A-D
Authors:	Ya-Hsiu Chuang (莊雅琇) Zih-You Huang Hsin-Ta Wang Shih-Hsiung Wu
Date:	2011
Issue Date:	2011-06-23 14:57:45 (UTC+8)
Abstract:	Aspergillus terreus found in Taiwan is the thermophilic filngus. In our previous study, its crude extract showed potential cytotoxity toward various tested human cancer cell lines. Based on the general partition and series chromatography, four new steroid derivatives Ergotetranone A-D (1-4) were isolated and determined, together with three known compounds, Ergosta-4,6,8(4),22-tetrane-3-one (5), Ergosta-5,7,22-trien-3β-ol (6), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (7). AII structures were identified by one-and two-dimensional NMR spectroscopy and Mass spectrometry. The investigation of biological activities of these steroid derivatives are under going.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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