One-pot Synthesis and Anti-HCV Activity Evaluation of New Anilinoquinoline Derivatives

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標題:	One-pot Synthesis and Anti-HCV Activity Evaluation of New Anilinoquinoline Derivatives
作者:	Huang-Kai Peng (彭皇凱) Cherng-Chyi Tzeng (曾誠齊) Jin-Ching Lee (李景欽) Shyh-Chyun Yang (楊世群)
日期:	2011
上傳時間:	2011-06-23 14:57:12 (UTC+8)
摘要:	Hepatitis C virus (HCV) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The objective of our research was to develop effective agents against viral replication. Here, we have one-pot synthesized a series of anilinoquinoline derivatives1,2. Based on a cell-based HCV replicon system, we observed that 2-(3'-nitroanilino)quinoline (18) exhibited anti-HCV activity with a 50% effective concentration (EC50) value of 7 μM and a selective index (SI) value of 10. We concluded that the compound 18 possessed a potent activity against HCV replication and could provide as a new lead compound as anti-HCV inhibitors.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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