One-pot Synthesis and Anti-HCV Activity Evaluation of New Anilinoquinoline Derivatives

CNU IR > Pharmacy and Science > 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium > Item 310902800/24219

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题名:	One-pot Synthesis and Anti-HCV Activity Evaluation of New Anilinoquinoline Derivatives
作者:	Huang-Kai Peng (彭皇凱) Cherng-Chyi Tzeng (曾誠齊) Jin-Ching Lee (李景欽) Shyh-Chyun Yang (楊世群)
日期:	2011
上传时间:	2011-06-23 14:57:12 (UTC+8)
摘要:	Hepatitis C virus (HCV) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The objective of our research was to develop effective agents against viral replication. Here, we have one-pot synthesized a series of anilinoquinoline derivatives1,2. Based on a cell-based HCV replicon system, we observed that 2-(3'-nitroanilino)quinoline (18) exhibited anti-HCV activity with a 50% effective concentration (EC50) value of 7 μM and a selective index (SI) value of 10. We concluded that the compound 18 possessed a potent activity against HCV replication and could provide as a new lead compound as anti-HCV inhibitors.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
显示于类别:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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