Synthesis  and Evaluation of Acyl Chain- and Galactose 6'- Modified Analogs of a-GalCer for NKT Cell Activation

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/24189

標題:	Synthesis and Evaluation of Acyl Chain- and Galactose 6'- Modified Analogs of a-GalCer for NKT Cell Activation
作者:	Ming-Han Hsieh (謝明翰) Jung-Tung Hung (洪榮堂) Alice L.Yu (陳玲津) Pi-Hui Liang (梁碧惠)
日期:	2011
上傳時間:	2011-06-23 14:56:45 (UTC+8)
摘要:	a-GalCer is an immunostimulating glycolipid which is known to bind to CD Id molecule and activate invariant natural killer T (/NKT) cells. Herein, we report the synthesis and in vitro evalualuation of a-GalCer analogs with modification at the acylside chain or/and galactose-6' position. Substitutions at galaciactose-6' of a-GalCer had a dominant effect on the NKT and T cell receptor (TCR) recognition, remarkably Gal 6'-phenylacetamide substituted with either p-nitro, p-tert-butyl, or (o, m)-methyl were four times more selective for T helper 1 (TH1) cytokine secretion against a-GalCer. These new glycolipids may find use as adjuvants or as antimetastatic agents.
關聯:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
顯示於類別:	[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
op-01.pdf		79Kb	Adobe PDF	660	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章