Synthesis  and Evaluation of Acyl Chain- and Galactose 6'- Modified Analogs of a-GalCer for NKT Cell Activation

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Title:	Synthesis and Evaluation of Acyl Chain- and Galactose 6'- Modified Analogs of a-GalCer for NKT Cell Activation
Authors:	Ming-Han Hsieh (謝明翰) Jung-Tung Hung (洪榮堂) Alice L.Yu (陳玲津) Pi-Hui Liang (梁碧惠)
Date:	2011
Issue Date:	2011-06-23 14:56:45 (UTC+8)
Abstract:	a-GalCer is an immunostimulating glycolipid which is known to bind to CD Id molecule and activate invariant natural killer T (/NKT) cells. Herein, we report the synthesis and in vitro evalualuation of a-GalCer analogs with modification at the acylside chain or/and galactose-6' position. Substitutions at galaciactose-6' of a-GalCer had a dominant effect on the NKT and T cell receptor (TCR) recognition, remarkably Gal 6'-phenylacetamide substituted with either p-nitro, p-tert-butyl, or (o, m)-methyl were four times more selective for T helper 1 (TH1) cytokine secretion against a-GalCer. These new glycolipids may find use as adjuvants or as antimetastatic agents.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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