Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/23217
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    標題: Effect of selected organo-sulfur compounds on melanin formation
    作者: Heuy-Ling Chu
    Bor-Sen Wang
    Pin-Der Duh
    貢獻者: 食品科技系
    關鍵字: Organo-sulfur compounds
    melanin
    tyrosinase
    reactive oxygen species
    日期: 2009-07
    上傳時間: 2010-11-15 11:27:11 (UTC+8)
    摘要: The effect of organo-sulfur compounds, including 1-propylmercaptan (PM), dimethyl disulfide (DMDS), diallyl disulfide (DADS), propyl disulfide (PDS), and 2,5-dimethylthiophene (DMT), on melanin formation was investigated. Among the selected five organo-sulfur compounds, PM displayed a significant inhibitory effect on tyrosinase activity (IC50 = 0.5 mM) and the highest inhibitory action on o-quinone formation. In the B16 intracellular model system, the inhibitory action of selected five organo-sulfur compounds on tyrosinase activity and melanin formation may be, in part, attributed to the reduction of the reactive oxygen species (ROS) formation and positive modulation of the GSH/GSSG ratio in B16 cells. Among the five organo-sulfur compounds, PM appeared to be the most potent inhibitor of melanin formation. The analysis of inhibitory kinetics revealed that PM is a mixed-type inhibitor. This is the first study indicating that organo-sulfur compounds tested may play an important role in the regulation of melanin formation, making them the potent candidates for skin-whitening agents.
    關聯: J.Agric Food Chem 57(15):p.7072-7077
    显示于类别:[ 食品科技系 ] 期刊論文

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