Effect of selected organo-sulfur compounds on melanin formation

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Title:	Effect of selected organo-sulfur compounds on melanin formation
Authors:	Heuy-Ling Chu Bor-Sen Wang Pin-Der Duh
Contributors:	食品科技系
Keywords:	Organo-sulfur compounds melanin tyrosinase reactive oxygen species
Date:	2009-07
Issue Date:	2010-11-15 11:27:11 (UTC+8)
Abstract:	The effect of organo-sulfur compounds, including 1-propylmercaptan (PM), dimethyl disulfide (DMDS), diallyl disulfide (DADS), propyl disulfide (PDS), and 2,5-dimethylthiophene (DMT), on melanin formation was investigated. Among the selected five organo-sulfur compounds, PM displayed a significant inhibitory effect on tyrosinase activity (IC50 = 0.5 mM) and the highest inhibitory action on o-quinone formation. In the B16 intracellular model system, the inhibitory action of selected five organo-sulfur compounds on tyrosinase activity and melanin formation may be, in part, attributed to the reduction of the reactive oxygen species (ROS) formation and positive modulation of the GSH/GSSG ratio in B16 cells. Among the five organo-sulfur compounds, PM appeared to be the most potent inhibitor of melanin formation. The analysis of inhibitory kinetics revealed that PM is a mixed-type inhibitor. This is the first study indicating that organo-sulfur compounds tested may play an important role in the regulation of melanin formation, making them the potent candidates for skin-whitening agents.
Relation:	J.Agric Food Chem 57(15)：p.7072-7077
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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