Antioxidant, Antioedema and Analgesic Activites of Andrographis panuculata Extracts and their Active Constituent Andrographolide

doi:10.1002/ptr.2701

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/23210

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標題:	Antioxidant, Antioedema and Analgesic Activites of Andrographis panuculata Extracts and their Active Constituent Andrographolide
作者:	F. L. Lin S. J. Wu S. C. Lee L. T. Ng4
貢獻者:	保健營養系
關鍵字:	Andrographis paniculata andrographolide antioxidant antioedema analgesic
日期:	2009-07
上傳時間:	2010-11-12 16:11:23 (UTC+8)
摘要:	Andrographis paniculata (AP), a popular ingredient of Oriental folk medicine, is commonly used for treating infection, inflammation, fever and diarrhoea. In this study, extracts prepared from cultivated AP and their active constituent andrographolide were evaluated for antioxidant, antioedema and analgesic activities. The results showed that the aqueous AP extract (AP-H2O) exhibited a greater antioxidant activity than the ethanol AP extract (AP-EtOH) in all model systems tested. At a concentration of 50 �g/mL, the free radical scavenging, xanthine oxidase inhibition and antilipid peroxidation activities for AP-H2O were 66.8%, 57.3% and 65.3%, respectively, and for AP-EtOH were 57.8%, 52.6% and 34.2%, respectively. At a dosage of 100 mg/kg, AP-H2O and andrographolide, but not AP-EtOH, showed antioedema and analgesic activities. In phytochemical analysis, AP-H2O showed a higher concentration of total flavanoid but a lower phenol content than AP-EtOH. In conclusion, AP-H2O was more potent than AP-EtOH in antioxidant activities. Furthermore, compared with andrographolide, AP-H2O as an extract also appears to possess potent antioedema and analgesic activities.
關聯:	Phytotherapy Research 23(7)：p.958-964
显示于类别:	[保健營養系(所) ] 期刊論文

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