Antioxidant, Antioedema and Analgesic Activites of Andrographis panuculata Extracts and their Active Constituent Andrographolide

doi:10.1002/ptr.2701

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/23210

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23210

Title:	Antioxidant, Antioedema and Analgesic Activites of Andrographis panuculata Extracts and their Active Constituent Andrographolide
Authors:	F. L. Lin S. J. Wu S. C. Lee L. T. Ng4
Contributors:	保健營養系
Keywords:	Andrographis paniculata andrographolide antioxidant antioedema analgesic
Date:	2009-07
Issue Date:	2010-11-12 16:11:23 (UTC+8)
Abstract:	Andrographis paniculata (AP), a popular ingredient of Oriental folk medicine, is commonly used for treating infection, inflammation, fever and diarrhoea. In this study, extracts prepared from cultivated AP and their active constituent andrographolide were evaluated for antioxidant, antioedema and analgesic activities. The results showed that the aqueous AP extract (AP-H2O) exhibited a greater antioxidant activity than the ethanol AP extract (AP-EtOH) in all model systems tested. At a concentration of 50 �g/mL, the free radical scavenging, xanthine oxidase inhibition and antilipid peroxidation activities for AP-H2O were 66.8%, 57.3% and 65.3%, respectively, and for AP-EtOH were 57.8%, 52.6% and 34.2%, respectively. At a dosage of 100 mg/kg, AP-H2O and andrographolide, but not AP-EtOH, showed antioedema and analgesic activities. In phytochemical analysis, AP-H2O showed a higher concentration of total flavanoid but a lower phenol content than AP-EtOH. In conclusion, AP-H2O was more potent than AP-EtOH in antioxidant activities. Furthermore, compared with andrographolide, AP-H2O as an extract also appears to possess potent antioedema and analgesic activities.
Relation:	Phytotherapy Research 23(7)：p.958-964
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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