Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits

doi:10.1016/j.ejphar.2009.01.013

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/23157

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標題:	Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits
作者:	Ko-Chi Niu Wu-Tein Huang Mao-Tsun Lin Kuo-Fong Huang
貢獻者:	休閒保健管理系
關鍵字:	Fever Lipopolysaccharide Glutamate Hydroxyl radical Hyperbaric oxygen Antipyresis Prostaglandin E2
日期:	2009-03
上傳時間:	2010-10-28 13:34:09 (UTC+8)
摘要:	Current study was attempted to assess whether hyperbaric oxygen pretreatment or treatment exerts its antipyresis by reducing circulating interleukin-6 and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E2 in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and hypothalamic levels of glutamate, hydroxyl radicals, and prostaglandin E2 accompanied by increased plasma levels of interleukin-6. The rise in both the core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E2 could also be induced by intracerebroventricular injection of interleukin-6. Pretreatment or treatment with hyperbaric oxygen significantly reduced the lipopolysaccharide-induced overproduction of circulating interleukin-6, and hypothalamic glutamate, prostaglandin E2, and hydroxyl radicals. The febrile response caused by central administration of interleukin-6 could also be suppressed by hyperbaric oxygen pretreatment or treatment. Simultaneous administration of an anti-oxidant (e.g., N-acetyl-l-cysteine) significantly enhanced the antipyretic effects exerted by hyperbaric oxygen treatment. These results indicate that hyperbaric oxygen pretreatment or treatment may exert its antipyresis by inhibiting the glutamate–hydroxyl radicals–prostaglandin-E2 pathways in the hypothalamus and circulating interleukin-6 accumulation during lipopolysaccharide-fever.
關聯:	Euro. J. Pharmacol. 606(1-3)：p.240-245
显示于类别:	[休閒保健管理系(所)] 期刊論文

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