Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits

doi:10.1016/j.ejphar.2009.01.013

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/23157

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23157

Title:	Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits
Authors:	Ko-Chi Niu Wu-Tein Huang Mao-Tsun Lin Kuo-Fong Huang
Contributors:	休閒保健管理系
Keywords:	Fever Lipopolysaccharide Glutamate Hydroxyl radical Hyperbaric oxygen Antipyresis Prostaglandin E2
Date:	2009-03
Issue Date:	2010-10-28 13:34:09 (UTC+8)
Abstract:	Current study was attempted to assess whether hyperbaric oxygen pretreatment or treatment exerts its antipyresis by reducing circulating interleukin-6 and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E2 in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and hypothalamic levels of glutamate, hydroxyl radicals, and prostaglandin E2 accompanied by increased plasma levels of interleukin-6. The rise in both the core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E2 could also be induced by intracerebroventricular injection of interleukin-6. Pretreatment or treatment with hyperbaric oxygen significantly reduced the lipopolysaccharide-induced overproduction of circulating interleukin-6, and hypothalamic glutamate, prostaglandin E2, and hydroxyl radicals. The febrile response caused by central administration of interleukin-6 could also be suppressed by hyperbaric oxygen pretreatment or treatment. Simultaneous administration of an anti-oxidant (e.g., N-acetyl-l-cysteine) significantly enhanced the antipyretic effects exerted by hyperbaric oxygen treatment. These results indicate that hyperbaric oxygen pretreatment or treatment may exert its antipyresis by inhibiting the glutamate–hydroxyl radicals–prostaglandin-E2 pathways in the hypothalamus and circulating interleukin-6 accumulation during lipopolysaccharide-fever.
Relation:	Euro. J. Pharmacol. 606(1-3)：p.240-245
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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