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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/23149

    標題: Effects of dietary flaxseed oil on cholesterol metabolism of hamsters
    作者: Bor-Show Tzang
    Shun-Fa Yang
    Shih-Guei Fu
    Hui-Chun Yang
    Hai-Lun Sun
    Yi-Chen Chen
    貢獻者: 生活應用與保健系
    關鍵字: Flaxseed oil
    Serum lipids
    Hepatic cholesterol/triacylglycerol contents
    Faecal cholesterol/triacylglycerol excretion
    HMG-CoA reductase
    LDL receptor
    日期: 2009-06
    上傳時間: 2010-10-27 16:27:41 (UTC+8)
    摘要: High-fat/cholesterol diets (HFCD) formulated by addition of butter (BU), coconut oil (CO), or flaxseed oil (FX) enhanced (P < 0.05) serum lipids of hamsters compared to the low-fat/cholesterol diet (Control). However, FX groups showed a hypocholesterolaemic effect compared to CO and BU groups. Lower (P < 0.05) hepatic triacylglycerol and cholesterol contents were measured in FX groups than those of CO and BU groups; whereas, higher (P < 0.05) faecal triacylglycerol and cholesterol contents were observed in FX groups. HMG-CoA reductase mRNA expression was upregulated (P < 0.05) by HFCD, whilst FX groups showed no (P > 0.05) influence on LDL-receptor mRNA expression compared to that of Control groups; however, higher (P < 0.05) than those of CO and BU groups. Meanwhile, there was a tendency towards higher CYP7A1 expression in the CO or FX group than the BU group. Thus, the hypocholesterolaemic effect of FX might result from increases of LDL-receptor mRNA expression, and cholesterol catabolism/output.
    關聯: Food Chemistry 114(4):p.1450-1455
    Appears in Collections:[生活應用與保健系] 期刊論文

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