Effects of dietary flaxseed oil on cholesterol metabolism of hamsters

doi:10.1016/j.foodchem.2008.11.030

CNU IR > College of Smart Living > Dept. of Life and Health Science > Periodical Articles > Item 310902800/23149

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/23149

Title:	Effects of dietary flaxseed oil on cholesterol metabolism of hamsters
Authors:	Bor-Show Tzang Shun-Fa Yang Shih-Guei Fu Hui-Chun Yang Hai-Lun Sun Yi-Chen Chen
Contributors:	生活應用與保健系
Keywords:	Flaxseed oil Serum lipids Hepatic cholesterol/triacylglycerol contents Faecal cholesterol/triacylglycerol excretion HMG-CoA reductase CYP7A1 LDL receptor
Date:	2009-06
Issue Date:	2010-10-27 16:27:41 (UTC+8)
Abstract:	High-fat/cholesterol diets (HFCD) formulated by addition of butter (BU), coconut oil (CO), or flaxseed oil (FX) enhanced (P < 0.05) serum lipids of hamsters compared to the low-fat/cholesterol diet (Control). However, FX groups showed a hypocholesterolaemic effect compared to CO and BU groups. Lower (P < 0.05) hepatic triacylglycerol and cholesterol contents were measured in FX groups than those of CO and BU groups; whereas, higher (P < 0.05) faecal triacylglycerol and cholesterol contents were observed in FX groups. HMG-CoA reductase mRNA expression was upregulated (P < 0.05) by HFCD, whilst FX groups showed no (P > 0.05) influence on LDL-receptor mRNA expression compared to that of Control groups; however, higher (P < 0.05) than those of CO and BU groups. Meanwhile, there was a tendency towards higher CYP7A1 expression in the CO or FX group than the BU group. Thus, the hypocholesterolaemic effect of FX might result from increases of LDL-receptor mRNA expression, and cholesterol catabolism/output.
Relation:	Food Chemistry 114(4)：p.1450-1455
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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