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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/23127

    標題: Tyrosinase Inhibitors isolated from the roots of Paeonia suffruticosa
    作者: Hsiou-Yu Ding
    Hang-Ching Lin
    Te-Sheng Chang
    貢獻者: 化粧品科技研究所
    日期: 2009-05
    上傳時間: 2010-10-26 16:01:00 (UTC+8)
    摘要: The inhibition of mushroom tyrosinase by Paeonia suffruticosa root-derived materials was evaluated. Six tyrosinase inhibitors were isolated by ethanol extraction, n-hexane, ethyl acetate, n-BuOH, and water partition, silica gel column chromatography, Sephadex LH-20, Lobar PR-8, and high-performance liquid chromatography methods, and they were identified as kaempferol (I), quercetin (II), mudanpioside B (III), benzoyloxypaeoniflorin (IV), mudanpioside H (V), and pentagalloyl-β-D-glucose (VI) on the basis of spectroscopic evidence. The inhibitory activities of compounds I to VI against mushroom tyrosinase were determined with IC50 values of 0.120, 0.108, 0.368, 0.453, 0.324, and 0.063 mM, respectively. The kinetic study indicated that all purified inhibitors acted competitively for the L-dopa binding site of the enzyme, with an exception of compound VI, which acted non-competitively.
    關聯: Journal of Cosmetic Science 60:p.347–352
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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