Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22602
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    標題: Local scaling and multifractal spectrum analyses of DNA sequences – GenBank data analysis
    作者: Zhi-Yuan Su
    Tzuyin Wu
    Shu-Yin Wang
    貢獻者: 資訊管理系
    日期: 2009-05
    上傳時間: 2010-04-13 14:09:55 (UTC+8)
    摘要: Base sequences of deoxyribonucleic acid (DNA) in an organism carry all the instructions regarding its growth
    and development. On the surface, such sequences seem irregular; yet in reality, they are symbolic sequences with an
    organized structure. This study investigates the characteristics of base arrangement and distribution in DNA
    sequences from the fractal theory viewpoint. In addition to multifractal features demonstrated by the DNA
    sequence, this study also compares the multifractal spectra derived from a particular family of gene among several
    different species. The results reveal that a considerable correlation exists between base distribution and evolutionary
    order. Furthermore, local scaling exponent (Ho¨ lder exponent) differences between coding segments (exon) and noncoding
    segments (intron) are also examined. It is suggested that such differences in the local distribution of bases
    can be applied to find coding segments within the DNA sequence that is to be translated into protein. This local
    scaling analysis is feasible and has the potential to become an effective tool for rapid location of possible coding
    sites in DNA sequences. The authors hope that future studies using more complicated bioinformatics methods for
    analyzing DNA sequences can benefit from this study.
    關聯: Chaos, Solitons and Fractals 40:p.1750-1765
    显示于类别:[資訊管理系] 期刊論文

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