Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/22209
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18074/20272 (89%)
造访人次 : 2568698      在线人数 : 1247
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/22209


    標題: A simplified gene-specific screen for Y chromosome deletions in infertile men.
    作者: Yen-Ni Teng
    Ying-Hung Lin
    Yung-Chieh Tsai
    Chao-Chin Hsu
    Pao-Lin Kuo
    Yung-Ming Lin
    貢獻者: 生物科技系
    關鍵字: Gene
    Y deletion
    male infertility
    日期: 2007-06
    上傳時間: 2010-01-12 09:13:18 (UTC+8)
    摘要: Objective
    To test the diagnostic efficiency of a gene-specific, five-marker screening strategy for the detection of Y chromosome deletions.
    Design
    Prospective case study.
    Setting
    University genetics laboratory and reproductive clinics.
    Patient(s)
    Six hundred twenty-seven infertile men and 212 fertile men.
    Intervention(s)
    Peripheral blood samples were screened for Y chromosome deletions in a triple-blind fashion using three protocols: protocol I consisted of five gene-specific markers, including USP9Y, DBY, SMCY, RBM1, and DAZ; protocol II included 14 gene-specific markers; and protocol III consisted of six sequence-tagged sites (STSs) markers recommended by EAA/EMQN.
    Main Outcome Measure(s)
    Deletion status of Y chromosome genes or sequence-tagged sites.
    Result(s)
    Protocols I and II identified the same 41 infertile patients with Y deletions. Protocol III identified 38 infertile patients with Y deletions, and all 38 patients were also identified by protocols I and II. One patient with isolated USP9Y deletion and two patients with isolated DBY deletions, as detected by protocols I and II, could not be identified by protocol III.
    Conclusion(s)
    We observed mostly consistent results between our protocols and the EAA/EMQN protocol. This gene-specific, five-marker screening panel provides the same diagnostic efficiency as the EAA/EMQN protocol and may be considered an alternative to the EAA/EMQN protocol.
    關聯: Fertility & Sterility 87(6)： p.1291-1300
    显示于类别:[生物科技系(所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    0KbHTML2146检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈