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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/22206

    標題: Chalcone Arrests Cell Cycle Progression and Induces Apoptosis through Induction of Mitochondrial Pathway and Inhibition of Nuclear Factor Kappa B Signalling in Human Bladder Cancer Cells.
    作者: SHEN Kun-Hung
    CHANG Jiunn-Kae
    HSU Ya-Ling
    KUO Po-Lin
    貢獻者: 生物科技系
    關鍵字: Human Breast-Cancer
    A549 Cells
    Fruiting Bodies
    日期: 2007-10
    上傳時間: 2010-01-12 09:13:14 (UTC+8)
    出版者: Blackwell Publishing
    摘要: Chalcones (l,3-diphenyl-2-propenone) are cancer preventive food components found in a human diet rich in fruits and vegetables. In this study, we first report the chemopreventive effect of chalcone in two human bladder cancer cell lines: T24 and HT-1376. The results show that chalcone inhibits the proliferation of T24 and HT-1376 cells by inducing apoptosis and blocking cell cycle progression in the G2/M phase. Western blot assay showed that chalcone significantly increases the expression of p21 and p27 proteins, and decreases the levels of cyclin Bl, cyclin A and Cdc2, thereby contributing to cell cycle arrest. In addition, chalcone increased the expression of Bax and Bak, but decreased the levels of Bcl-2 and Bcl-XL and subsequently triggered mitochondrial apoptotic pathway (release of cytochrome c and activation of caspase-9 and caspase-3). Our study suggests that the induction of mitochondrial pathway and inhibition of the nuclear factor kappa B survival system may play important roles in the antiproliferative activity of chalcone in T24 and HT-1376 cells.
    關聯: Basic & clinical pharmacology & toxicology 101(4): p.254-261
    Appears in Collections:[生物科技系(所)] 期刊論文

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