Chalcone Arrests Cell Cycle Progression and Induces Apoptosis through Induction of Mitochondrial Pathway and Inhibition of Nuclear Factor Kappa B Signalling in Human Bladder Cancer Cells.

doi:10.1111/j.1742-7843.2007.00120.x

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/22206

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Title:	Chalcone Arrests Cell Cycle Progression and Induces Apoptosis through Induction of Mitochondrial Pathway and Inhibition of Nuclear Factor Kappa B Signalling in Human Bladder Cancer Cells.
Authors:	SHEN Kun-Hung CHANG Jiunn-Kae HSU Ya-Ling KUO Po-Lin
Contributors:	生物科技系
Keywords:	Human Breast-Cancer Prostate-Cancer A549 Cells Angelica-Keiskei Fruiting Bodies Carcinoma Proliferation Therapy Xanthoangelol Constituent
Date:	2007-10
Issue Date:	2010-01-12 09:13:14 (UTC+8)
Publisher:	Blackwell Publishing
Abstract:	Chalcones (l,3-diphenyl-2-propenone) are cancer preventive food components found in a human diet rich in fruits and vegetables. In this study, we first report the chemopreventive effect of chalcone in two human bladder cancer cell lines: T24 and HT-1376. The results show that chalcone inhibits the proliferation of T24 and HT-1376 cells by inducing apoptosis and blocking cell cycle progression in the G2/M phase. Western blot assay showed that chalcone significantly increases the expression of p21 and p27 proteins, and decreases the levels of cyclin Bl, cyclin A and Cdc2, thereby contributing to cell cycle arrest. In addition, chalcone increased the expression of Bax and Bak, but decreased the levels of Bcl-2 and Bcl-XL and subsequently triggered mitochondrial apoptotic pathway (release of cytochrome c and activation of caspase-9 and caspase-3). Our study suggests that the induction of mitochondrial pathway and inhibition of the nuclear factor kappa B survival system may play important roles in the antiproliferative activity of chalcone in T24 and HT-1376 cells.
Relation:	Basic & clinical pharmacology & toxicology 101(4)： p.254-261
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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