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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21734

    標題: Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway
    作者: Yi-Ming Chiang
    Edyta Szewczyk
    Tania Nayak
    Ashley D. Davidson
    James F. Sanchez
    Hsien-Chun Lo
    Wen-Yueh Ho
    Hagop Simityan
    Eric Kuo
    Alex Praseuth
    Kenji Watanabe
    Berl R. Oakley
    Clay C.C. Wang
    貢獻者: 藥物科技研究所
    日期: 2008-06
    上傳時間: 2009-10-13 09:29:40 (UTC+8)
    出版者: Cell Press
    摘要: The recently sequenced genomes of several Aspergillus species have revealed that these organisms have the potential to produce a surprisingly large range of natural products, many of which are currently unknown. We have found that A. nidulans produces emericellamide A, an antibiotic compound of mixed origins with polyketide and amino acid building blocks. Additionally, we describe the discovery of four previously unidentified, related compounds that we designate emericellamide C–F. Using recently developed gene targeting techniques, we have identified the genes involved in emericellamide biosynthesis. The emericellamide gene cluster contains one polyketide synthase and one nonribosomal peptide synthetase. From the sequences of the genes, we are able to deduce a biosynthetic pathway for the emericellamides. The identification of this biosynthetic pathway opens the door to engineering novel analogs of this structurally complex metabolite.
    關聯: Chemistry and Biology 15(6):p.527-532
    Appears in Collections:[藥學系(所)] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文

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