Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway

doi:10.1016/j.chembiol.2008.05.010

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/21734

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21734

Title:	Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway
Authors:	Yi-Ming Chiang Edyta Szewczyk Tania Nayak Ashley D. Davidson James F. Sanchez Hsien-Chun Lo Wen-Yueh Ho Hagop Simityan Eric Kuo Alex Praseuth Kenji Watanabe Berl R. Oakley Clay C.C. Wang
Contributors:	藥物科技研究所化粧品應用與管理系
Date:	2008-06
Issue Date:	2009-10-13 09:29:40 (UTC+8)
Publisher:	Cell Press
Abstract:	The recently sequenced genomes of several Aspergillus species have revealed that these organisms have the potential to produce a surprisingly large range of natural products, many of which are currently unknown. We have found that A. nidulans produces emericellamide A, an antibiotic compound of mixed origins with polyketide and amino acid building blocks. Additionally, we describe the discovery of four previously unidentified, related compounds that we designate emericellamide C–F. Using recently developed gene targeting techniques, we have identified the genes involved in emericellamide biosynthesis. The emericellamide gene cluster contains one polyketide synthase and one nonribosomal peptide synthetase. From the sequences of the genes, we are able to deduce a biosynthetic pathway for the emericellamides. The identification of this biosynthetic pathway opens the door to engineering novel analogs of this structurally complex metabolite.
Relation:	Chemistry and Biology 15(6)：p.527-532
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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