Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia

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標題:	Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia
作者:	Min-Hsiung Pan Chiu-Ming Chen Shwu-Woan Lee Zong-Tsi Chen
貢獻者:	醫藥化學系 10.1002/cbdv.200890053
關鍵字:	Helicteres angustifolia Triterpenoids Cytotoxic activity
日期:	2008-04
上傳時間:	2009-10-13 09:09:32 (UTC+8)
出版者:	Wiley-V C H Verlag Gmbh
摘要:	Three new triterpenoids, 3-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.
關聯:	Chemistry & Biodiversity 5(4)：p.565-574
顯示於類別:	[食藥產業暨檢測科技系(含五專)] 期刊論文

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