Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia

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Title:	Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia
Authors:	Min-Hsiung Pan Chiu-Ming Chen Shwu-Woan Lee Zong-Tsi Chen
Contributors:	醫藥化學系 10.1002/cbdv.200890053
Keywords:	Helicteres angustifolia Triterpenoids Cytotoxic activity
Date:	2008-04
Issue Date:	2009-10-13 09:09:32 (UTC+8)
Publisher:	Wiley-V C H Verlag Gmbh
Abstract:	Three new triterpenoids, 3-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.
Relation:	Chemistry & Biodiversity 5(4)：p.565-574
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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