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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21721


    標題: Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata
    作者: Shwu-Woan Lee
    Min-Hsiung Pan
    Chiu-Ming Chen
    Zong-Tsi Chen
    貢獻者: 醫藥化學系
    關鍵字: Physalis angulata
    Solanaceae
    withanolide
    withangulatin
    日期: 2008-02
    上傳時間: 2009-10-13 09:09:29 (UTC+8)
    摘要: A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15α-acetoxy-5β,6β-epoxy-14α-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC50 values of 16.6 and 1.8 and 53.6 and 65.4 μM, respectively.
    關聯: Chemical & Pharmaceutical Bulletin 56(2):p.234-236
    Appears in Collections:[食藥產業暨檢測科技系(含五專)] 期刊論文

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