English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18055/20253 (89%)
Visitors : 24604710      Online Users : 475
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21721

    標題: Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata
    作者: Shwu-Woan Lee
    Min-Hsiung Pan
    Chiu-Ming Chen
    Zong-Tsi Chen
    貢獻者: 醫藥化學系
    關鍵字: Physalis angulata
    日期: 2008-02
    上傳時間: 2009-10-13 09:09:29 (UTC+8)
    摘要: A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15α-acetoxy-5β,6β-epoxy-14α-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC50 values of 16.6 and 1.8 and 53.6 and 65.4 μM, respectively.
    關聯: Chemical & Pharmaceutical Bulletin 56(2):p.234-236
    Appears in Collections:[食藥產業暨檢測科技系(含五專)] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback