Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

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Title:	Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata
Authors:	Shwu-Woan Lee Min-Hsiung Pan Chiu-Ming Chen Zong-Tsi Chen
Contributors:	醫藥化學系
Keywords:	Physalis angulata Solanaceae withanolide withangulatin
Date:	2008-02
Issue Date:	2009-10-13 09:09:29 (UTC+8)
Abstract:	A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15α-acetoxy-5β,6β-epoxy-14α-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC50 values of 16.6 and 1.8 and 53.6 and 65.4 μM, respectively.
Relation:	Chemical & Pharmaceutical Bulletin 56(2)：p.234-236
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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