Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery

doi:10.1111/j.1399-6576.2007.01525.x

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/21589

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21589

Title:	Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery
Authors:	T. F. WANG Y. H. LIU C. C. CHU J. P. SHIEH J. I. TZENG J. J. WANG 褚錦承
Contributors:	休閒保健管理系
Keywords:	Antiemetics droperidol haloperidol laparoscopic surgery post-operative nausea and vomiting
Date:	2008-02
Issue Date:	2009-07-23 10:28:41 (UTC+8)
Abstract:	Background: We evaluated the prophylactic effect of low-dose haloperidol (1 mg) on post-operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls. Methods: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. After tracheal intubation, the haloperidol group (n=50) received intravenous haloperidol (1 mg), the droperidol group (n=50) received intravenous droperidol (0.625 mg), and the saline group (n=50) received intravenous saline. Results: Haloperidol- and droperidol-group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P<0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P<0.05] during the first four post-operative hours. During the 24-h post-operative period, haloperidol- and droperidol-group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P<0.01]. No differences were found between the haloperidol and droperidol groups. Conclusion: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery.
Relation:	Acta anaesthesiologica scandinavica 52(2)：p.280-284
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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