Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery

doi:10.1111/j.1399-6576.2007.01525.x

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/21589

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標題:	Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery
作者:	T. F. WANG Y. H. LIU C. C. CHU J. P. SHIEH J. I. TZENG J. J. WANG 褚錦承
貢獻者:	休閒保健管理系
關鍵字:	Antiemetics droperidol haloperidol laparoscopic surgery post-operative nausea and vomiting
日期:	2008-02
上傳時間:	2009-07-23 10:28:41 (UTC+8)
摘要:	Background: We evaluated the prophylactic effect of low-dose haloperidol (1 mg) on post-operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls. Methods: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. After tracheal intubation, the haloperidol group (n=50) received intravenous haloperidol (1 mg), the droperidol group (n=50) received intravenous droperidol (0.625 mg), and the saline group (n=50) received intravenous saline. Results: Haloperidol- and droperidol-group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P<0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P<0.05] during the first four post-operative hours. During the 24-h post-operative period, haloperidol- and droperidol-group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P<0.01]. No differences were found between the haloperidol and droperidol groups. Conclusion: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery.
關聯:	Acta anaesthesiologica scandinavica 52(2)：p.280-284
显示于类别:	[休閒保健管理系(所)] 期刊論文

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