Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (Soft Corals) are Capable of Inhibiting the Growth of Human Oral Squamous Cell Carcinoma Cells

doi:10.3390/md6040595

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/21563

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標題:	Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (Soft Corals) are Capable of Inhibiting the Growth of Human Oral Squamous Cell Carcinoma Cells
作者:	Chia-Hua Liang Guey-Horng Wang Chih-Chuang Liaw Mei-Feng Lee Shih-Hao Wang Da-Long Cheng Tzung-Han Chou 梁家華
貢獻者:	化粧品應用與管理系
關鍵字:	Soft corals Cladiella australis Clavularia viridis Klyxum simplex Apoptosis
日期:	2008-11
上傳時間:	2009-07-20 11:08:24 (UTC+8)
摘要:	Many biomedical products have already been obtained from marine organisms. In order to search more therapeutic drugs against cancer, this study demonstrates the cytotoxicity effects of Cladiella australis, Clavularia viridis and Klyxum simplex extracts on human oral squamous cell carcinoma (SCC4, SCC9 and SCC25) cells using cell adhesion and cell viability assay. The morphological alterations in SCCs cells after treatment with three extracts, such as typical nuclear condensation, nuclear fragmentation and apoptotic bodies of cells were demonstrated by Hoechst stain. Flow cytometry indicated that three extracts sensitized SCC25 cells in the G0/G1 and S-G2/M phases with a concomitant significantly increased sub-G1 fraction, indicating cell death by apoptosis. This apoptosis process was accompanied by activation of caspase-3 expression after SCC25 cells were treated with three extracts. Thereby, it is possible that extracts of C. australis, C. viridis and K. simplex cause apoptosis of SCCs and warrant further research investigating the possible anti-oral cancer compounds in these soft corals.
link:	http://dx.doi.org/10.3390/md6040595
關聯:	Marine drugs 6(4)：p.595-606
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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