Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21563
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    Title: Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (Soft Corals) are Capable of Inhibiting the Growth of Human Oral Squamous Cell Carcinoma Cells
    Authors: Chia-Hua Liang
    Guey-Horng Wang
    Chih-Chuang Liaw
    Mei-Feng Lee
    Shih-Hao Wang
    Da-Long Cheng
    Tzung-Han Chou
    梁家華
    Contributors: 化粧品應用與管理系
    Keywords: Soft corals
    Cladiella australis
    Clavularia viridis
    Klyxum simplex
    Apoptosis
    Date: 2008-11
    Issue Date: 2009-07-20 11:08:24 (UTC+8)
    Abstract: Many biomedical products have already been obtained from marine organisms. In order to search more therapeutic drugs against cancer, this study demonstrates the cytotoxicity effects of Cladiella australis, Clavularia viridis and Klyxum simplex extracts on human oral squamous cell carcinoma (SCC4, SCC9 and SCC25) cells using cell adhesion and cell viability assay. The morphological alterations in SCCs cells after treatment with three extracts, such as typical nuclear condensation, nuclear fragmentation and apoptotic bodies of cells were demonstrated by Hoechst stain. Flow cytometry
    indicated that three extracts sensitized SCC25 cells in the G0/G1 and S-G2/M phases with a concomitant significantly increased sub-G1 fraction, indicating cell death by apoptosis. This apoptosis process was accompanied by activation of caspase-3 expression after SCC25 cells were treated with three extracts. Thereby, it is possible that extracts of C. australis, C. viridis and K. simplex cause apoptosis of SCCs and warrant further research investigating the possible anti-oral cancer compounds in these soft corals.
    ???metadata.dc.relation.uri???: http://dx.doi.org/10.3390/md6040595
    Relation: Marine drugs 6(4):p.595-606
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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