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https://ir.cnu.edu.tw/handle/310902800/21562
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| 標題: | Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu |
| 作者: | Shiu, L. Y.
Liang, C. H.
Huang, Y. S.
Sheu, H. M.
Kuo, K. W. |
| 貢獻者: | 化粧品應用與管理系 |
| 關鍵字: | Solamargine
HER2/neu
Topoisomerase II
Methotrexate
5-Fluorouracil
Cisplatin |
| 日期: | 2008-01 |
| 上傳時間: | 2009-07-20 11:08:22 (UTC+8) |
| 出版者: | Springer |
| 摘要: | Overexpression of HER2/neu is associated with drug resistance and poor outcome in breast cancer. Solamargine (SM), a glycoalkaloid purified from the herb Solanum incanum, exhibits HER2/neu gene modulation of HER2/neu high-expressing human breast cancer cell line ZR-75-1. SM downregulation of HER2/neu gene expression was determined by RT-PCR and Southern hybridization. Additionally, the membrane-bound HER2/neu receptor in highly HER2/neu-expressing breast cancer cells was determined by radioimmunoassay, immunocytochemistry, fluorescent immunocytochemistry, and flow cytometry. SM significantly decreased the number of HER2/neu receptors on the cell membrane. Methotrexate (MTX), 5-florouracil (5-Fu), and cisplatin (CDDP) are commonly used for breast carcinoma treatment in clinics; however, patients with HER2/neu overexpression exhibit resistance to these anticancer drugs. Notably, combination of MTX, 5-Fu, and CDDP with SM individually increased the susceptibility of breast cancer cells to these chemotherapeutic agents. Experimental results indicated that downregulation of HER2/neu by SM might be an effective strategy for enhancing drug susceptibility of breast cancer cells expressing high levels of HER2/neu. |
| 關聯: | Cell biology and toxicology 24(1)：p.1-10 |
| 显示于类别: | [化妝品應用與管理系(所)] 期刊論文
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