Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21562
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    题名: Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu
    作者: Shiu, L. Y.
    Liang, C. H.
    Huang, Y. S.
    Sheu, H. M.
    Kuo, K. W.
    贡献者: 化粧品應用與管理系
    关键词: Solamargine
    HER2/neu
    Topoisomerase II
    Methotrexate
    5-Fluorouracil
    Cisplatin
    日期: 2008-01
    上传时间: 2009-07-20 11:08:22 (UTC+8)
    出版者: Springer
    摘要: Overexpression of HER2/neu is associated with drug resistance and poor outcome in breast cancer. Solamargine (SM), a glycoalkaloid purified from the herb Solanum incanum, exhibits HER2/neu gene modulation of HER2/neu high-expressing human breast cancer cell line ZR-75-1. SM downregulation of HER2/neu gene expression was determined by RT-PCR and Southern hybridization. Additionally, the membrane-bound HER2/neu receptor in highly HER2/neu-expressing breast cancer cells was determined by radioimmunoassay, immunocytochemistry, fluorescent immunocytochemistry, and flow cytometry. SM significantly decreased the number of HER2/neu receptors on the cell membrane. Methotrexate (MTX), 5-florouracil (5-Fu), and cisplatin (CDDP) are commonly used for breast carcinoma treatment in clinics; however, patients with HER2/neu overexpression exhibit resistance to these anticancer drugs. Notably, combination of MTX, 5-Fu, and CDDP with SM individually increased the susceptibility of breast cancer cells to these chemotherapeutic agents. Experimental results indicated that downregulation of HER2/neu by SM might be an effective strategy for enhancing drug susceptibility of breast cancer cells expressing high levels of HER2/neu.
    關聯: Cell biology and toxicology 24(1)：p.1-10
    显示于类别:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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