CD36 is a glycoprotein with an 88 kDa molecular weight. CD36 is expressed on platelets, macrophages, endothelial cells, and adipocytes. It has been reported that CD36 play an important role in the process of up taking oxidized low-density protein by macrophages. It have been known that CD36 is highly up-regulated at the transcriptional level by MCSF, native and modified LDL. CD36 is down regulated by corticosteroids, TGF-B1 and LPS, consistent with the idea that CD36 expression is down regulation during inflammation. A critical regulator of CD36 expression is the nuclear hormone receptor PPARr. In this study, we attempt to clarify the effect of black bean extract on the intracellular cholesterol content.
