This study is aimed to explore
whether Welsh onion extracts could affect
ATP-binding cassette-A1 (ABCA1)
protein expression in macrophage RAW
264.7 cells. Several studies have
established that the ABCA1 transporter
facilitates the efflux of cellular
phospholipids and cholesterol to
apolipoprotein acceptors and results in the
formation of pre- high-density
lipoprotein (HDL). The ABCA1
transporter not only is present on the cell
surface but also has a recycling pathwayto
the endocytic compartment of the cell,
which may play a pivotal role in mediating
intracellular trafficking of cholesterol to
the cell surface for efflux.
