研究含皮膚促進劑之各種基劑與皮膚接觸後，以ATR (attenated total reflection) 傅立葉轉換紅外線光譜儀 (FTIR)測定氨茶鹼在皮膚之傳送。由於存在光譜帶的N-H鍵頻率特性，可提供氨茶鹼在皮膚的吸收。研究三種皮膚促進劑(植物油、精油及親油性物質)，以親油性物質 β- cyclodextrin對氨茶鹼促進吸收最大。 The delivery of aminophylline from several vehicles, including those containing penetration enhancers, was investigated in human skin. The skin after contact with the aminophylline formulation was examined by attenated total reflection (ATR) - Fourier transform infrared (FTIR) spectroscopy. The presence of spectral bands at frequencies characteristic of N-H bonds provides evidence for the adsorption of the aminophylline on skin. Of the three kinds penetration enhancers ( plant oils, essentials oils and lipophilicities) were studied, β- cyclodextrin exhibited the largest increase intransdemal delivery when various enhancers were used .
