我們的研究顯示了豐富的環境可以增加大腦海馬迴的腦源神經滋養因子【brain-derived neurotrophic factor（BDNF）】和磷酸化的細胞間訊息調節激酶【phospho-extracellrlar signal-regulated protein kinase（P-ERK）】的量。初步的結果，我們發現豐富的環境能改善早期癲癇對空間的學習和記憶的不足。豐富的環境治療可以改善空間的學習效果，這可能是經由反複地刺激 BDNF 表現以活化其下游的信號途徑。 There is unequivocal clinical and experimental evidence that status epilepticus (SE) can lead to brain damage. Understanding the cellular and molecular mechanisms that contribute to epilepsy is critical for the development of new therapeutic approaches. Use of lithium-pilocarpine as a model for studying status epilepticus and status epilepticus-induced brain damage and epileptogenesis has been well described.
Environmental factor results in many modifications in the brain such as structural, behavioral, and biochemical changes. Enriched Environment (EE) can reverse enduring effects on cognition resulted from early neuronal insults. Environmental factors can have profound influences on the brain. A multitude of responses from cellular and molecular mechanisms to macroscopic changes in neural morphology and neurogenesis have been considered in that environmental factor inputs can regulate brain plasticity. The environmental enrichment model was applied in animal studies, which is the most widely known model of environmental factor-induced neural plasticity.
Our study have revealed that enriched environment increased brain-derived neurotrophic factor (BDNF) and phospho-extracellular signal-regulated protein kinase (P-ERK) levels in the hippocampus. The preliminary result, we found that enriched environment can rescues spatial learning and memory deficit following early-life status epileptic. Enriched environment treatment improves spatial learning, possibly via stimulating BDNF expression repetitively to activate its downstream signal pathway.