English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17330/19636 (88%)
Visitors : 4578484      Online Users : 377
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/9135


    標題: 利用豐富的環境可以來改善癲癇對空間記憶的不足
    Enriched Environment Rescues Spatial Memory Deficit Following Status Epilepticus
    作者: 孟慶鼎
    Chin-Ting Meng
    貢獻者: 林恆弘
    黃立同
    嘉南藥理科技大學:生物科技研究所
    關鍵字: 磷酸化的細胞間訊息調節激酶
    腦源神經滋養因子
    豐富的環境
    癲癇
    P-ERK
    phospho-extracellular signal-regulated protein k
    BDNF
    brain-derived neurotrophic factor
    EE
    Enriched Environment
    SE
    Status epilepticus
    日期: 2006
    上傳時間: 2008-11-24 17:02:39 (UTC+8)
    摘要: 在臨床與實驗上已有明確的證據證明癲癇會導致腦部的損傷。因此了解細胞與分子生物的作用機制對於治療癲癇會有重大的發展與貢獻。Lithium-Pilocarpine 用在老鼠上,可作為癲癇重積症及癲癇形成的動物模型。
    環境的因子造成腦部神經元的釵h改變,例如結構、行為和生化等的改變。豐富的環境(Enriched Environment;EE)治療能恢復因早期腦部神經元損傷所造成認知弁鉬棆炕C環境的因子能對腦有極深的影響能力。從細胞和分子的機制到巨觀的改變其反應在神經形態學和神經新生上,都認為環境因子的加入是可以調控腦神經元的可塑性。豐富的環境模型已應用在動物研究中,也是運用在神經的可塑性的最廣泛地的模型之一。
    我們的研究顯示了豐富的環境可以增加大腦海馬迴的腦源神經滋養因子【brain-derived neurotrophic factor(BDNF)】和磷酸化的細胞間訊息調節激酶【phospho-extracellrlar signal-regulated protein kinase(P-ERK)】的量。初步的結果,我們發現豐富的環境能改善早期癲癇對空間的學習和記憶的不足。豐富的環境治療可以改善空間的學習效果,這可能是經由反複地刺激 BDNF 表現以活化其下游的信號途徑。
    There is unequivocal clinical and experimental evidence that status epilepticus (SE) can lead to brain damage. Understanding the cellular and molecular mechanisms that contribute to epilepsy is critical for the development of new therapeutic approaches. Use of lithium-pilocarpine as a model for studying status epilepticus and status epilepticus-induced brain damage and epileptogenesis has been well described.
    Environmental factor results in many modifications in the brain such as structural, behavioral, and biochemical changes. Enriched Environment (EE) can reverse enduring effects on cognition resulted from early neuronal insults. Environmental factors can have profound influences on the brain. A multitude of responses from cellular and molecular mechanisms to macroscopic changes in neural morphology and neurogenesis have been considered in that environmental factor inputs can regulate brain plasticity. The environmental enrichment model was applied in animal studies, which is the most widely known model of environmental factor-induced neural plasticity.
    Our study have revealed that enriched environment increased brain-derived neurotrophic factor (BDNF) and phospho-extracellular signal-regulated protein kinase (P-ERK) levels in the hippocampus. The preliminary result, we found that enriched environment can rescues spatial learning and memory deficit following early-life status epileptic. Enriched environment treatment improves spatial learning, possibly via stimulating BDNF expression repetitively to activate its downstream signal pathway.
    關聯: 校內外完全公開
    Appears in Collections:[生物科技系(所)] 博碩士論文

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML460View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback