利用豐富的環境可以來改善癲癇對空間記憶的不足

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標題:	利用豐富的環境可以來改善癲癇對空間記憶的不足 Enriched Environment Rescues Spatial Memory Deficit Following Status Epilepticus
作者:	孟慶鼎 Chin-Ting Meng
貢獻者:	林恆弘黃立同嘉南藥理科技大學：生物科技研究所
關鍵字:	磷酸化的細胞間訊息調節激酶腦源神經滋養因子豐富的環境癲癇 P-ERK phospho-extracellular signal-regulated protein k BDNF brain-derived neurotrophic factor EE Enriched Environment SE Status epilepticus
日期:	2006
上傳時間:	2008-11-24 17:02:39 (UTC+8)
摘要:	在臨床與實驗上已有明確的證據證明癲癇會導致腦部的損傷。因此了解細胞與分子生物的作用機制對於治療癲癇會有重大的發展與貢獻。Lithium-Pilocarpine 用在老鼠上，可作為癲癇重積症及癲癇形成的動物模型。環境的因子造成腦部神經元的釵h改變，例如結構、行為和生化等的改變。豐富的環境（Enriched Environment；EE）治療能恢復因早期腦部神經元損傷所造成認知弁鉬棆炕C環境的因子能對腦有極深的影響能力。從細胞和分子的機制到巨觀的改變其反應在神經形態學和神經新生上，都認為環境因子的加入是可以調控腦神經元的可塑性。豐富的環境模型已應用在動物研究中，也是運用在神經的可塑性的最廣泛地的模型之一。我們的研究顯示了豐富的環境可以增加大腦海馬迴的腦源神經滋養因子【brain-derived neurotrophic factor（BDNF）】和磷酸化的細胞間訊息調節激酶【phospho-extracellrlar signal-regulated protein kinase（P-ERK）】的量。初步的結果，我們發現豐富的環境能改善早期癲癇對空間的學習和記憶的不足。豐富的環境治療可以改善空間的學習效果，這可能是經由反複地刺激 BDNF 表現以活化其下游的信號途徑。 There is unequivocal clinical and experimental evidence that status epilepticus (SE) can lead to brain damage. Understanding the cellular and molecular mechanisms that contribute to epilepsy is critical for the development of new therapeutic approaches. Use of lithium-pilocarpine as a model for studying status epilepticus and status epilepticus-induced brain damage and epileptogenesis has been well described. Environmental factor results in many modifications in the brain such as structural, behavioral, and biochemical changes. Enriched Environment (EE) can reverse enduring effects on cognition resulted from early neuronal insults. Environmental factors can have profound influences on the brain. A multitude of responses from cellular and molecular mechanisms to macroscopic changes in neural morphology and neurogenesis have been considered in that environmental factor inputs can regulate brain plasticity. The environmental enrichment model was applied in animal studies, which is the most widely known model of environmental factor-induced neural plasticity. Our study have revealed that enriched environment increased brain-derived neurotrophic factor (BDNF) and phospho-extracellular signal-regulated protein kinase (P-ERK) levels in the hippocampus. The preliminary result, we found that enriched environment can rescues spatial learning and memory deficit following early-life status epileptic. Enriched environment treatment improves spatial learning, possibly via stimulating BDNF expression repetitively to activate its downstream signal pathway.
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