Comparison of high-dose, short-course levofloxacin treatment vs conventional regimen against acute bacterial infection: meta-analysis of randomized controlled trials

doi:10.2147/IDR.S193483

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標題:	Comparison of high-dose, short-course levofloxacin treatment vs conventional regimen against acute bacterial infection: meta-analysis of randomized controlled trials
作者:	Chih-Wei Chen(陳志偉) Chen, Yu-Hung Cheng, I-Ling Lai, Chih-Cheng
貢獻者:	Chi Mei Med Ctr, Div Neurosurg, Dept Surg Chia Nan Univ Pharm & Sci, Inst Ind Safety & Disaster Prevent, Dept Occupat Safety & Hlth, Coll Sustainable Environm Chi Mei Med Ctr, Dept Pharm Chi Mei Med Ctr, Dept Intens Care Med
關鍵字:	levofloxacin acute bacterial infection community-acquired pneumonia complicated urinary tract infection acute sinusitis
日期:	2019
上傳時間:	2020-07-29 13:52:03 (UTC+8)
出版者:	DOVE MEDICAL PRESS LTD
摘要:	Objects: This meta-analysis aims to assess the efficacy and safety of high-dose, short-dose levofloxacin in comparison with conventional therapy on treating acute bacterial infection. Methods: PubMed, Embase and Cochrane database were searched up to September 2018. Only randomized controlled trials (RCTs) evaluating high-dose, short-course levofloxacin and conventional regimen in the treatment of acute bacterial infection were included. The primary outcomes were clinical responses, microbiologic eradication and adverse effects. Results: Seven RCTs of 3,731 patients (1,835 in the high-dose, short-course levofloxacin regimen group and 1,896 in the conventional regimen group) were included. Overall, no significant difference between the high-dose, short-course levofloxacin regimen group and the conventional regimen was found in terms of clinical response (risk ratio, RR: 1.01; 95% CI: 0.98-1.04, I-2=10%). In addition, the high-dose, short-course levofloxacin regimen had a similar microbiological eradication rate to conventional regimen (RR: 1.02; 95% CI: 0.98-1.06, I-2=0%). Moreover, the high-dose, short-course levofloxacin regimen had a similar incidence of treatment-emergent adverse events to conventional regimen (RR: 1.07; 95% CI: 0.99-1.17, I-2=0%). This trend was not affected by the different types of infections-community-acquired pneumonia, complicated urinary tract infection/acute pyelonephritis or acute sinusitis, different conventional regimen-levofloxacin (500 mg daily for 7-14 days) or ciprofloxacin (400 mg IV or 500 mg oral, twice daily for 10 days). Conclusion: High-dose, short-course levofloxacin exhibits similar clinical success and microbiologic eradication rates with conventional regimen in the treatment of acute bacterial infection. Moreover, the high-dose, short-course levofloxacin regimen was well tolerated and had comparable safety profiles with the conventional regimen.
關聯:	Infection and Drug Resistance, v.12, pp.1353-1361
显示于类别:	[職業安全衛生系(含防災所)] 期刊論文

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