Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32611
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23362873      Online Users : 485
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/32611


    Title: Comparison of high-dose, short-course levofloxacin treatment vs conventional regimen against acute bacterial infection: meta-analysis of randomized controlled trials
    Authors: Chih-Wei Chen(陳志偉)
    Chen, Yu-Hung
    Cheng, I-Ling
    Lai, Chih-Cheng
    Contributors: Chi Mei Med Ctr, Div Neurosurg, Dept Surg
    Chia Nan Univ Pharm & Sci, Inst Ind Safety & Disaster Prevent, Dept Occupat Safety & Hlth, Coll Sustainable Environm
    Chi Mei Med Ctr, Dept Pharm
    Chi Mei Med Ctr, Dept Intens Care Med
    Keywords: levofloxacin
    acute bacterial infection
    community-acquired pneumonia
    complicated urinary tract infection
    acute sinusitis
    Date: 2019
    Issue Date: 2020-07-29 13:52:03 (UTC+8)
    Publisher: DOVE MEDICAL PRESS LTD
    Abstract: Objects: This meta-analysis aims to assess the efficacy and safety of high-dose, short-dose levofloxacin in comparison with conventional therapy on treating acute bacterial infection. Methods: PubMed, Embase and Cochrane database were searched up to September 2018. Only randomized controlled trials (RCTs) evaluating high-dose, short-course levofloxacin and conventional regimen in the treatment of acute bacterial infection were included. The primary outcomes were clinical responses, microbiologic eradication and adverse effects. Results: Seven RCTs of 3,731 patients (1,835 in the high-dose, short-course levofloxacin regimen group and 1,896 in the conventional regimen group) were included. Overall, no significant difference between the high-dose, short-course levofloxacin regimen group and the conventional regimen was found in terms of clinical response (risk ratio, RR: 1.01; 95% CI: 0.98-1.04, I-2=10%). In addition, the high-dose, short-course levofloxacin regimen had a similar microbiological eradication rate to conventional regimen (RR: 1.02; 95% CI: 0.98-1.06, I-2=0%). Moreover, the high-dose, short-course levofloxacin regimen had a similar incidence of treatment-emergent adverse events to conventional regimen (RR: 1.07; 95% CI: 0.99-1.17, I-2=0%). This trend was not affected by the different types of infections-community-acquired pneumonia, complicated urinary tract infection/acute pyelonephritis or acute sinusitis, different conventional regimen-levofloxacin (500 mg daily for 7-14 days) or ciprofloxacin (400 mg IV or 500 mg oral, twice daily for 10 days). Conclusion: High-dose, short-course levofloxacin exhibits similar clinical success and microbiologic eradication rates with conventional regimen in the treatment of acute bacterial infection. Moreover, the high-dose, short-course levofloxacin regimen was well tolerated and had comparable safety profiles with the conventional regimen.
    Relation: Infection and Drug Resistance, v.12, pp.1353-1361
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    10.2147-IDR.S193483.pdf1255KbAdobe PDF382View/Open
    index.html0KbHTML912View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback