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    標題: Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature
    作者: Ansari, Ahmed N.
    Bobos, Mattheos
    Shih, Shawn
    Mark Chien-Chin Chen(陳建欽)
    Ardakani, Nima M.
    Rosales, Cecilia M.
    Chen, Chih-Jung
    Savage, Christopher
    Bracey, Tim
    McKee, Phillip H.
    Cerruto, Carlos A.
    貢獻者: Univ Cent Florida, Coll Med, Orlando
    Microdiagnostics Ltd
    Hellen Fdn Canc Res, Mol Oncol Lab
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
    QEII Med Ctr, PathWest Lab Med, Nedlands
    SEPA Labs, Southeastern Pathol Associates
    Changhua Christian Hosp, Dept Surg Pathol
    Chung Shan Med Univ, Sch Med
    Mid Florida Dermatol & Plast Surg
    Royal Cornwall Hosp, Truro
    Plymouth Hosp NHS Trust, Plymouth
    Brigham & Womens Hosp, Dept Surg Pathol
    Mid Florida Pathol
    關鍵字: endocrine mucin-producing sweat gland carcinoma
    primary cutaneous mucinous carcinoma
    renal cell carcinoma antigen
    review
    case series
    日期: 2019-08
    上傳時間: 2020-07-29 13:50:23 (UTC+8)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    摘要: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are both uncommon low-grade cutaneous adnexal tumors with predilection for the eyelids of elderly women. Their clinical appearance is nonspecific, typically presenting as a slowly growing poorly circumscribed papule, nodule, plaque, or swelling. Histological features of EMPSGC include a lobulated dermal neoplasm with bland cytology and an invasive mucinous component in up to half of the cases. PCMC exhibits tumor nests suspended in abundant pools of mucin with focal strands or nests of tumor cells infiltrating the dermis. Because of their rarity and banal cytological features, both entities pose a risk for misdiagnosis with other benign/malignant cutaneous adnexal neoplasms. Histomorphological features can suggest a diagnosis of EMPSGC or PCMC, but immunohistochemistry is necessary for confirmation. A review of the literature showed variable results of antigens present in EMPSGC, and many of the positive markers only show sparse or focal immunoreactivity of tumor cells. As a result, diffusely positive markers play a crucial role in identification of these tumors, particularly with initial superficial biopsies. We present 9 cases of EMPSGC and 5 cases of PCMC with strong and diffuse immunoreactivity to renal cell carcinoma antigen. This novel finding can be useful in the diagnosis of EMPSGC and PCMC in combination with other known positive markers to differentiate them from other cutaneous neoplasms. In addition, it provides further evidence that EMPSGC could be a precursor lesion to PCMC with both existing on a spectrum.
    關聯: American Journal of Dermatopathology, v.41, n.8, pp.571-577
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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