Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature

doi:10.1097/DAD.0000000000001370

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/32572

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Title:	Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature
Authors:	Ansari, Ahmed N. Bobos, Mattheos Shih, Shawn Mark Chien-Chin Chen(陳建欽) Ardakani, Nima M. Rosales, Cecilia M. Chen, Chih-Jung Savage, Christopher Bracey, Tim McKee, Phillip H. Cerruto, Carlos A.
Contributors:	Univ Cent Florida, Coll Med, Orlando Microdiagnostics Ltd Hellen Fdn Canc Res, Mol Oncol Lab Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol QEII Med Ctr, PathWest Lab Med, Nedlands SEPA Labs, Southeastern Pathol Associates Changhua Christian Hosp, Dept Surg Pathol Chung Shan Med Univ, Sch Med Mid Florida Dermatol & Plast Surg Royal Cornwall Hosp, Truro Plymouth Hosp NHS Trust, Plymouth Brigham & Womens Hosp, Dept Surg Pathol Mid Florida Pathol
Keywords:	endocrine mucin-producing sweat gland carcinoma primary cutaneous mucinous carcinoma renal cell carcinoma antigen review case series
Date:	2019-08
Issue Date:	2020-07-29 13:50:23 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are both uncommon low-grade cutaneous adnexal tumors with predilection for the eyelids of elderly women. Their clinical appearance is nonspecific, typically presenting as a slowly growing poorly circumscribed papule, nodule, plaque, or swelling. Histological features of EMPSGC include a lobulated dermal neoplasm with bland cytology and an invasive mucinous component in up to half of the cases. PCMC exhibits tumor nests suspended in abundant pools of mucin with focal strands or nests of tumor cells infiltrating the dermis. Because of their rarity and banal cytological features, both entities pose a risk for misdiagnosis with other benign/malignant cutaneous adnexal neoplasms. Histomorphological features can suggest a diagnosis of EMPSGC or PCMC, but immunohistochemistry is necessary for confirmation. A review of the literature showed variable results of antigens present in EMPSGC, and many of the positive markers only show sparse or focal immunoreactivity of tumor cells. As a result, diffusely positive markers play a crucial role in identification of these tumors, particularly with initial superficial biopsies. We present 9 cases of EMPSGC and 5 cases of PCMC with strong and diffuse immunoreactivity to renal cell carcinoma antigen. This novel finding can be useful in the diagnosis of EMPSGC and PCMC in combination with other known positive markers to differentiate them from other cutaneous neoplasms. In addition, it provides further evidence that EMPSGC could be a precursor lesion to PCMC with both existing on a spectrum.
Relation:	American Journal of Dermatopathology, v.41, n.8, pp.571-577
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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