Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32201
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    標題: Raspberry ketone induces brown-like adipocyte formation through suppression of autophagy in adipocytes and adipose tissue
    作者: Leu, Sy-Ying
    Tsai, Yung-Chieh
    Chen, Wen-Chi
    Hsu, Chih-Hsiung
    Lee, Yen-Mei
    Cheng, Pao-Yun
    貢獻者: Natl Def Med Ctr, Grad Inst Life Sci
    Chi Mei Med Ctr, Dept Obstet & Gynecol
    Taipei Med Univ, Dept Med
    Chia Nan Univ Pharm & Sci, Dept Sport Management
    Natl Def Med Ctr, Grad Inst Physiol, Dept Physiol & Biophys
    Natl Def Med Ctr, Triserv Gen Hosp, Dept Internal Med
    Natl Def Med Ctr, Dept Pharmacol
    關鍵字: Raspberry ketone
    3T3-L1 Adipocyte
    Beige adipocyte
    日期: 2018-06
    上傳時間: 2019-11-15 15:44:59 (UTC+8)
    摘要: Promoting white adipose tissue (WAT) to acquire brown-like characteristics is a promising approach for obesity treatment. Although raspberry ketone (RK) has been reported to possess antiobesity activity, its effects on the formation of brown-like adipocytes remain unclear. Therefore, we investigated the effects and underlying mechanism of RK on WAT browning in 313-L1 adipocytes and rats with ovariectomy (Ovx)-induced obesity. RK (100 mu M) significantly induced browning of 3T3-L1 cells by increasing mitochondrial biogenesis and the expression of browning-specific proteins (PR domain containing 16, PRDM16; peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1 alpha; uncoupling protein-1, UCP-1) and lipolytic enzymes (hormone-sensitive lipase and adipose triglyceride lipase). RK significantly reduced the expression of the autophagy-related protein Atg12 and increased the expression of p62 and heme oxygenase 1 (1-10-1). Additionally, these effects of RK were reversed by the HO-1 inhibitor SnPP (20 mu M). In addition, RK (160 mg/kg, gavage, for 8 weeks) significantly reduced body weight gain (Ovx+ RK, 191.8 + 4.6 g vs. Ovx, 223.6 +/- 5.9; P < .05), food intake, the amount of inguinal adipose tissue (Ovx+ RK, 9.05 +/- 1.1 g vs Ovx, 12.9 +/- 0.92 g; P < .05) and the size of white adipocytes in Ovx rats. Moreover, compared to expression in the Ovx group, the levels of browning-specific proteins were significantly higher and the levels of autophagy-related proteins were significantly lower in the Ovx+RK group. Therefore, this study elucidated the mechanism associated with RK-induced WAT browning and thus provides evidence to support the clinical use of RK for obesity treatment. (C) 2018 Elsevier Inc. All rights reserved.
    關聯: World Neurosurgery, v.56, pp.116-125
    显示于类别:[運動管理系] 期刊論文


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