Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32201
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17524/19853 (88%)
Visitors : 6472129      Online Users : 669
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item:

    Title: Raspberry ketone induces brown-like adipocyte formation through suppression of autophagy in adipocytes and adipose tissue
    Authors: Leu, Sy-Ying
    Tsai, Yung-Chieh
    Chen, Wen-Chi
    Hsu, Chih-Hsiung
    Lee, Yen-Mei
    Cheng, Pao-Yun
    Contributors: Natl Def Med Ctr, Grad Inst Life Sci
    Chi Mei Med Ctr, Dept Obstet & Gynecol
    Taipei Med Univ, Dept Med
    Chia Nan Univ Pharm & Sci, Dept Sport Management
    Natl Def Med Ctr, Grad Inst Physiol, Dept Physiol & Biophys
    Natl Def Med Ctr, Triserv Gen Hosp, Dept Internal Med
    Natl Def Med Ctr, Dept Pharmacol
    Keywords: Raspberry ketone
    3T3-L1 Adipocyte
    Beige adipocyte
    Date: 2018-06
    Issue Date: 2019-11-15 15:44:59 (UTC+8)
    Abstract: Promoting white adipose tissue (WAT) to acquire brown-like characteristics is a promising approach for obesity treatment. Although raspberry ketone (RK) has been reported to possess antiobesity activity, its effects on the formation of brown-like adipocytes remain unclear. Therefore, we investigated the effects and underlying mechanism of RK on WAT browning in 313-L1 adipocytes and rats with ovariectomy (Ovx)-induced obesity. RK (100 mu M) significantly induced browning of 3T3-L1 cells by increasing mitochondrial biogenesis and the expression of browning-specific proteins (PR domain containing 16, PRDM16; peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1 alpha; uncoupling protein-1, UCP-1) and lipolytic enzymes (hormone-sensitive lipase and adipose triglyceride lipase). RK significantly reduced the expression of the autophagy-related protein Atg12 and increased the expression of p62 and heme oxygenase 1 (1-10-1). Additionally, these effects of RK were reversed by the HO-1 inhibitor SnPP (20 mu M). In addition, RK (160 mg/kg, gavage, for 8 weeks) significantly reduced body weight gain (Ovx+ RK, 191.8 + 4.6 g vs. Ovx, 223.6 +/- 5.9; P < .05), food intake, the amount of inguinal adipose tissue (Ovx+ RK, 9.05 +/- 1.1 g vs Ovx, 12.9 +/- 0.92 g; P < .05) and the size of white adipocytes in Ovx rats. Moreover, compared to expression in the Ovx group, the levels of browning-specific proteins were significantly higher and the levels of autophagy-related proteins were significantly lower in the Ovx+RK group. Therefore, this study elucidated the mechanism associated with RK-induced WAT browning and thus provides evidence to support the clinical use of RK for obesity treatment. (C) 2018 Elsevier Inc. All rights reserved.
    Relation: World Neurosurgery, v.56, pp.116-125
    Appears in Collections:[Dept. of Sports Management] Periodical Articles

    Files in This Item:

    File SizeFormat

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback