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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31776

    標題: Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats
    作者: Hung, Ching-Hsia
    Chiu, Chong-Chi
    Liu, Kuo-Sheng
    Chen, Yu-Wen
    Wang, Jhi-Joung
    貢獻者: Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy
    Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
    Southern Taiwan Univ Sci & Technol, Dept Elect Engn
    Chi Mei Med Ctr, Dept Gen Surg
    Chi Mei Med Ctr, Dept Gen Surg
    Chia Nan Univ Pharm & Sci, Dept Pharm
    China Med Univ, Coll Hlth Care, Dept Phys Therapy
    China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care
    Chi Mei Med Ctr, Dept Med Res
    關鍵字: Elicits Cutaneous Analgesia
    Isobolographic Analysis
    Infiltrative Anesthesia
    Inguinal Herniorrhaphy
    Systemic Toxicity
    日期: 2017-05
    上傳時間: 2018-11-30 15:56:19 (UTC+8)
    出版者: Lippincott Williams & Wilkins
    摘要: Background: The purpose of this experiment was to investigate the interactions of the local anesthetic lidocaine combined with an agent (serotonin or dopamine) as infiltrative anesthetics. Methods: Cutaneous analgesia was characterized by the blockade of the cutaneous trunci muscle reflex following 6 skin pinpricks on the rat back. Serotonin or dopamine at producing cutaneous analgesia in a dosage-dependent fashion was compared with lidocaine. Drug-drug interactions were calculated using the isobolographic analysis. Results: We revealed that serotonin, dopamine, and lidocaine provoked dose-related cutaneous analgesic effects. On the 50% effective dose basis, the rank of drugs' potency was found to be serotonin (1.70 [1.56-1.85] mu mol) > lidocaine (5.18 [4.67-5.75] mu mol) > dopamine (43.0 [40.9-45.2] mu mol) (P < 0.01). At doses equivalent to their 25%, 50%, and 75% effective doses, serotonin or dopamine elicited a longer duration of action than lidocaine (P < 0.01) on producing cutaneous analgesia. Coadministration of serotonin or dopamine with lidocaine produced a synergistic effect. Conclusions: The preclinical data showed that serotonin and dopamine produce dose-related cutaneous analgesic effects as an infiltrative anesthetic. Serotonin has a better potency with a much longer duration of action compared with lidocaine at provoking cutaneous analgesia. Serotonin or dopamine as an adjuvant increases the quality of lidocaine in cutaneous analgesia.
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