Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats

doi:10.1097/AAP.0000000000000552

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Title:	Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats
Authors:	Hung, Ching-Hsia Chiu, Chong-Chi Liu, Kuo-Sheng Chen, Yu-Wen Wang, Jhi-Joung
Contributors:	Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci Southern Taiwan Univ Sci & Technol, Dept Elect Engn Chi Mei Med Ctr, Dept Gen Surg Chi Mei Med Ctr, Dept Gen Surg Chia Nan Univ Pharm & Sci, Dept Pharm China Med Univ, Coll Hlth Care, Dept Phys Therapy China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care Chi Mei Med Ctr, Dept Med Res
Keywords:	Elicits Cutaneous Analgesia Isobolographic Analysis Spinal-Anesthesia Local-Anesthesia Infiltrative Anesthesia Inguinal Herniorrhaphy Systemic Toxicity Action-Potentials Bupivacaine Epinephrine
Date:	2017-05
Issue Date:	2018-11-30 15:56:19 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	Background: The purpose of this experiment was to investigate the interactions of the local anesthetic lidocaine combined with an agent (serotonin or dopamine) as infiltrative anesthetics. Methods: Cutaneous analgesia was characterized by the blockade of the cutaneous trunci muscle reflex following 6 skin pinpricks on the rat back. Serotonin or dopamine at producing cutaneous analgesia in a dosage-dependent fashion was compared with lidocaine. Drug-drug interactions were calculated using the isobolographic analysis. Results: We revealed that serotonin, dopamine, and lidocaine provoked dose-related cutaneous analgesic effects. On the 50% effective dose basis, the rank of drugs' potency was found to be serotonin (1.70 [1.56-1.85] mu mol) > lidocaine (5.18 [4.67-5.75] mu mol) > dopamine (43.0 [40.9-45.2] mu mol) (P < 0.01). At doses equivalent to their 25%, 50%, and 75% effective doses, serotonin or dopamine elicited a longer duration of action than lidocaine (P < 0.01) on producing cutaneous analgesia. Coadministration of serotonin or dopamine with lidocaine produced a synergistic effect. Conclusions: The preclinical data showed that serotonin and dopamine produce dose-related cutaneous analgesic effects as an infiltrative anesthetic. Serotonin has a better potency with a much longer duration of action compared with lidocaine at provoking cutaneous analgesia. Serotonin or dopamine as an adjuvant increases the quality of lidocaine in cutaneous analgesia.
Relation:	Regional Anesthesia and Pain Medicine, v.42, n.3, pp.351-356
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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