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    標題: The relationship of depression in asthma - chronic obstructive pulmonary disease overlap syndrome
    作者: Yeh, Jun-Jun
    Lin, Cheng-Li
    Hsu, Wu-Huei
    Kao, Chia-Hung
    貢獻者: Ditmanson Med Fdn,Chia Yi Christian Hosp
    Chia Nan Univ Pharm & Sci
    Meiho Univ
    China Med Univ Hosp, Management Off Hlth Data
    China Med Univ, Coll Med
    China Med Univ, Coll Med, Grad Inst Clin Med Sci
    China Med Univ, Coll Med, Sch Med
    China Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med
    China Med Univ Hosp, Dept Nucl Med
    China Med Univ Hosp, PET Ctr
    Asia Univ, Dept Bioinformat & Med Engn
    關鍵字: Quality-Of-Life
    Copd-Overlap
    Prevalence
    Corticosteroids
    Population
    Anxiety
    Impact
    日期: 2017-12-12
    上傳時間: 2018-11-30 15:56:04 (UTC+8)
    出版者: Public Library Science
    摘要: Purpose To clarify the relationship between asthma - chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. Methods We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts. Results The risk of depression was higher in the ACOS cohort than in the non-ACOS cohort (adjusted hazard ratios (aHRs) = 1.67, 95% confidence interval [CI] = 1.48 - 1.88). In the ACOS cohort, the aHRs for depression were [2.44 (95% CI = 1.45 - 4.11); 2.36 (95% CI = 1.58 - 3.52)] in patients [aged 20 - 39 years; without comorbidity]. In the ACOS cohort, the aHRs for depression were 1.70 (95% CI = 1.51 - 1.93) and 1.84 (95% CI = 1.55 - 2.19) in patients without inhaled corticosteroids (ICSs) and oral steroids (OSs) use, respectively. Moreover, the aHRs for the risk of depression were 1.16 (95% CI = 0.95 - 1.41) and 1.12 (95% CI = 0.96 - 1.29) in patients with ICSs and OSs use, respectively. Conclusion The risk of depression is higher in ACOS patients, even in those without comorbidities or in young adults. The events of the depression were not significant difference in patients receiving the ICSs/OSs between the ACOS and the non-ACOS cohorts.
    關聯: Plos One, v.12, n.12, e0188017
    Appears in Collections:[嬰幼兒保育系] 期刊論文

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